United States securities and exchange commission logo November 13, 2020 Michael Bailey President & Chief Executive Officer AVEO Pharmaceuticals, Inc. 30 Winter Street Boston, Massachusetts 02108 Re: AVEO Pharmaceuticals, Inc. Registration Statement on Form S-3 Filed November 9, 2020 File No. 333-249982 Dear Mr. Bailey: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Tim Buchmiller at (202) 551-3635 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Cynthia T. Mazareas, Esq.